Seven Ages of a Leader Essay Example for Free

Seven Ages of a Leader Essay Each stages of leadership brings new crises and challenges. Every new leader faces the misperceptions and the personal needs and agendas of those who are to be led. The seven ages of leadership give a clear idea about the different stages of leadership. They are, †¢The Infant Executive †¢The Schoolboy with shining face †¢The Lover ,with a woeful ballad †¢The Bearded Soldier †¢The General, Full of wise saws †¢The statesman, with spectacles Nose †¢The sage, second childishness The initial stage of the leader says that the leader is like a child and he needs others dependency and support. He do everything with the support of others. The next stage is like a school boy with shining face. In that time the leadership experience is an agonizing education like parenting. In the third stage the leader is the lover with a woeful ballad. One mark of the future leaders is the ability to identify. Today’s leaders would instantly recognize the young king’s predicament. New comer or not , almost all leaders find themselves at some point in the position of having to ask others to leave the organization. In the fourth age of the leadership is like the bearded soldier. At the case of over time leaders grow comfortable with the role. This comfort brings more confidence to the leaders In this stage leaders may forget the true impact of their words and actions at that the leader think that there is no need for hearing what the followers said . In this stage the leader acts very strictly and adopt a seriousness character The next age of leadership is like the general with full of wise saws. One of the greatest challenges faced by the leader is that the leader’s career is not simply allowing people to speak the truth but actually being able to hear it. In this stage the leader is with the feature of wise saws. In the fifth stage the leader is like a statesman , with spectacles. The leader in this stage is often hard at work he prepare something for the benefit of the organization. In the last age of leadership the leader is again go to the childishness this is called second stage childishness In this stage the leader acts as a mentor and he really know what he have achieved will not be lost.

Impact of Packing Elements on Consumer Buying Behavior

Impact of Packing Elements on Consumer Buying Behavior Introduction Nowadays consumers have become more and more conscious about the packaging available to them from products. The role of packaging has changed over the years since primarily due to the changing lifestyles and needs of the consumers. Companies have started bring innovations in packaging since their beliefs over the years have changed that good and unique packaging can stimulate consumer buying behaviors. It has become the source of customers attraction towards products or services, increases the image of the brand and increases the perceptions of the consumer for the product (Rundh 2005). In marketing context packaging plays a very vital role in communicating the product to the consumers and ultimately increases consumers purchase decisions. According to Underwood, Klein Burke, 2001; Silayoi Speece, 2004 a good package communicates unique values about products, and also helps in differentiating the products from other products, hence helping the consumers in choosing the right produc t from a wide range of similar products, and as a result stimulates consumers buying behaviors. (Wells, Farley Armstrong, 2007). In the past the primary function of packaging was to protect the product, but nowadays according the changing marketing environments packaging is being used as a tool for promoting sales, attracting customers and communicating the product to the consumers. (Kotler et al. 1998). The major objectives of a good packaging, which should be achieved are that is should be able to identify the product to the consumer, conveys descriptive and persuasive information about the product, facilitates the product protection and transportation, aid product consumption, and assists at-home storage. Consumers in daily life are exposed to a very wide range of products having different packaging ranging from different product categories displayed in markets, supermarkets and any other place of shopping. Products can then be differentiated from the external packaging having different shapes, sizes, colors, labeling, etc. what is actually inside the package can only be judged through a creative and innovative packaging. The issue here arises that can a good package design impact consumers buying behaviors? Does packaging color impact the behaviors? Do innovations impact these behaviors? Do the labels on packaging impact these behaviors? It is very easy gaining examples from our daily lives. The package design helps the consumer is judging what the package is carrying. If we take the example of Nestle Orange Juice the package reveals that the product contains a very healthy orange juice. The package design should be able to communicate to the consumer what the product is. According t o Schoormanns and Robben (1997) a new package design can be negatively related to the consumers influences of taste perceptions. This is likely due to the consumers past experiences with the product, the perceptions they develop by judging the product by its packaging design. Thus it is very important that the packaging design is the key to developing consumers perceptions about the product or brand. These perceptions may be negative or positive, so it is essential for marketers to bring creativeness and innovations in the packaging design. Consumers are very much likely to judge the product on the basis of price, package color, design, labeling etc. (Implicit Product Theory of Pinson 1986). Background Problem Formulation Previous Studies Deficiencies Significance Purpose Statement The purpose of this cross-sectional survey study is to determine the impact of Packaging Elements on Consumer Buying Behavior in Pakistan. In this context Quantitative Method has been used, the purpose of this survey is to study the various packaging elements that influence the consumers buying behavior. The present study focuses on packaging elements including design, color, labeling, and innovations. Packaging is a wide term in which different elements describe and identify a product or service. It is considered a science, art and technology which not only protects, stores, and distributes a product but also helps the consumer in identifying a product (Wiki). Orth Malkewitz 2006; Underwood Klein 2002 argue that the importance of packaging is increasing due to the increased significance it is playing in buying decisions in store, the presence of it at the time of purchase decisions, and its ability to reach to a wider audience of product purchasers. Rundh 2005 further argues that packaging has the ability of differentiating products from each other. In todays global and competitive environment, packaging can also provide a source of competitive advantage. This study will identify the impacts of packaging elements on the consumer buying behavior in Pakistan using questionnaire survey method. Significance of Study The topic under research will study the impact of packaging elements on consumer buying behavior of Pakistan. For this purpose four packaging elements have been selected; packaging color, design, innovation and printed information. According to Cruden 1989, over the years the, introduction of new packaging concepts have accelerated. This study will be of value in a number of ways. The topic of research is highly under researched and least research has been done regarding the impact of packaging elements on consumer buying behavior of Pakistan. This study will not only help the marketers in bringing innovations and creativeness into the packaging of products but will also provide the policy makers in implementing effective decisions in bringing changes and creative strategies in packaging. This study will contribute immensely through Quantitative research. Theoretically Practically Methodologically Theoretical Framework Theoretical Stances Model: Color pPa Design Consumer Buying Behavior Printed Information Innovation Research Objectives Main Objective The main objective of the study is to: To determine the impact of packaging elements on consumer buying behavior of Pakistan. Sub Objectives The sub objectives of the study are: To provide a basis for future research and to facilitate the administration in implementing and introducing effective and creative packaging elements in order to influence the consumers buying behavior in a positive way. Research Questions and Hypothesis Main Research Question Impact of Packaging Elements on Consumer Buying Behavior. Hypothesis H1 = Does package color influence the consumer buying behavior? H2 = Packaging design has an impact on consumer buying behavior? H3 = Does labeling influence the consumer buying behavior? H4 = Do innovations in packaging impact the buying behaviors? Chapter 2 Literature Review Introduction Nowadays consumers have become more and more conscious about the packaging available to them from products. The role of packaging has changed over the years since primarily due to the changing lifestyles and needs of the consumers. Companies have started bring innovations in packaging since their beliefs over the years have changed that good and unique packaging can stimulate consumer buying behaviors. It has become the source of customers attraction towards products or services, increases the image of the brand and increases the perceptions of the consumer for the product (Rundh 2005), further argued by Rita Kuvykaite (2009) that a package attracts the attention of the consumers for a particular brand. In marketing context packaging plays a very vital role in communicating the product to the consumers and ultimately increases consumers purchase decisions. According to Underwood, Klein Burke, 2001; Silayoi Speece, 2004 a good package communicates unique values about products, and a lso helps in differentiating the products from other products, hence helping the consumers in choosing the right product from a wide range of similar products, and as a result stimulates consumers buying behaviors. (Wells, Farley Armstrong, 2007). It has become a significant issue that the consumers buying behaviors are influenced by the packaging elements. According to Kotler 2003 six packaging elements are the important elements that should be evaluated while employing packaging decisions, these include; size of package, package form, package material, color, text and the brand using that package. According to a study conducted by Bed Nath Sharma in 2008, the respondents response was 84.37% in which they responded that product labels are a simple tag which is attached to any product or consider it as a graphical design which an essential part of a package. In another study in support of packaging belongs to Alice Louw (2006) in which he studied the responses of university students in which it was concluded that in the marketing arena packaging has played a very vital role and he concluded that the right packaging helps in creating unique place in the market as well as in the minds of the consumers. In another research conducted by Renaud Lunardo (2007) the impacts of label on particular brand consumption showed that many consumers buying behavior has been influenced by the labeling. In support of packaging influencing the buying behavior of consumers another study has been conducted by Bytyqi Hysen Vegara Mensur (2008) on how consumers purchase or buy diary products in Kosovo. The results that generated from the research show that majority of the respondents feel that packaging has much to do while purchasing diary products. Various studies have found that packaging is a mean of attracting customers attention towards a product (Underwood et al., 2001; Garber et al., 2000; Goldberg et al, 1999; Schoormans Robben, 1997). Goldberg et al. (1999) emphasized that if non-verbal communication like colors etc, if they are removed from packaging and the use of verbal communication is increased (like images) then it highly attracts the customers specially when the brand in unfamiliar with the consumers. (Underwood et al., 2001). Futher it is argued that package color (Gordon et al., 1994), name of brand (Rigaux-Bricmont, 1981), and package material (McDaniel Baker, 1977) all communicate the meaning of the brand to the consumer. Despite these finding researchers argue that physical appearance is not all that attract consumers towards a particular brand (Garber et al., 2000; Schoormans Robben 1997) while others argue that package colors and shapes are the main source of product attraction and attention (Garber et al., 2000; Schoormans Robben 1997). According to a research conducted by Pires Gon (2008) it is unable for the consumers to preceive what a product is all about, they heavily rely upon the packaging of any product. So the essential packaging elements are the color and shape of the package as well as labeling which communicate the product message to the consumers. Literature Flow Diagram Packaging Elements Color Design Labeling Innovation Conclusion Introduction Consumer Buying Behavior: History of consumerà ¢Ã¢â€š ¬Ã‚ ¦ Packaging Color Consumer Buying Behavior: Packaging Design Consumer Buying Behavior: Bridging the gapà ¢Ã¢â€š ¬Ã‚ ¦. dkvà ¢Ã¢â€š ¬Ã‚ ¦ Packaging Labeling Consumer Buying Behavior: Packaging Innovation Consumer Buying Behavior: Summary Chapter 3 Methodology This chapter deals with the methodology used in investigating the collected data. A systematic way has been provided which includes the procedures taken for the purposes of data collection and analysis. Introduction For the purpose of this research Quantitative Research Method has been used. Paradigm: Research Approach: The research approach used in this study is Quantitative Research. For this purpose a self administered questionnaire was designed. Research Design: Quantitative research approach is implied in this study in which questionnaires will be undertaken for the purpose of data collection. The questionnaire respondents were the employees of the Telecom sector. (Sampling, validity reliability, cross sectional survey) Research Site: Population/Sample: For the purpose of data collection the site selected for this study includes general consumers from which the data has been selected. Strategy of Inquiry: Method: Data collection method was questionnaire which was self administered. The method of sampling was random sampling. Survey method has been used Validity and Reliability: Reliability means that the result is applicable whereas validity means that the measurement are accurate and whether they are measuring what they intend to measure. In reliability checked the results through statistical procedure of internal consistency. To increase the reliability of questionnaire a pilot test was made from 5 respondents. Errors and ambiguities were removed during this process. Analysis Procedure: After setting the sample size, site, the tool for data collection, various analyses were done using SPSS. Summary Chapter 4 Analysis and Results Introduction Analysis and Results Summary Chapter 5 Discussion Conclusion and Recommendations Introduction Discussion Conclusion Suggestions and Recommendations Impact of Packing Elements on Consumer Buying Behavior Impact of Packing Elements on Consumer Buying Behavior Nowadays consumers have become more and more conscious about the packaging available to them from products. The role of packaging has changed over the years since primarily due to the changing lifestyles and needs of the consumers. Companies have started bring innovations in packaging since their beliefs over the years have changed that good and unique packaging can stimulate consumer buying behaviors. It has become the source of customers attraction towards products or services, increases the image of the brand and increases the perceptions of the consumer for the product (Rundh 2005). In marketing context packaging plays a very vital role in communicating the product to the consumers and ultimately increases consumers purchase decisions. According to Underwood, Klein Burke, 2001; Silayoi Speece, 2004 a good package communicates unique values about products, and also helps in differentiating the products from other products, hence helping the consumers in choosing the right produc t from a wide range of similar products, and as a result stimulates consumers buying behaviors. (Wells, Farley Armstrong, 2007). In the past the primary function of packaging was to protect the product, but nowadays according the changing marketing environments packaging is being used as a tool for promoting sales, attracting customers and communicating the product to the consumers. (Kotler et al. 1998). The major objectives of a good packaging, which should be achieved are that is should be able to identify the product to the consumer, conveys descriptive and persuasive information about the product, facilitates the product protection and transportation, aid product consumption, and assists at-home storage. Consumers in daily life are exposed to a very wide range of products having different packaging ranging from different product categories displayed in markets, supermarkets and any other place of shopping. Products can then be differentiated from the external packaging having different shapes, sizes, colors, labeling, etc. what is actually inside the package can only be judged through a creative and innovative packaging. The issue here arises that can a good package design impact consumers buying behaviors? Does packaging color impact the behaviors? Do innovations impact these behaviors? Do the labels on packaging impact these behaviors? It is very easy gaining examples from our daily lives. The package design helps the consumer is judging what the package is carrying. If we take the example of Nestle Orange Juice the package reveals that the product contains a very healthy orange juice. The package design should be able to communicate to the consumer what the product is. According t o Schoormanns and Robben (1997) a new package design can be negatively related to the consumers influences of taste perceptions. This is likely due to the consumers past experiences with the product, the perceptions they develop by judging the product by its packaging design. Thus it is very important that the packaging design is the key to developing consumers perceptions about the product or brand. These perceptions may be negative or positive, so it is essential for marketers to bring creativeness and innovations in the packaging design. Consumers are very much likely to judge the product on the basis of price, package color, design, labeling etc. (Implicit Product Theory of Pinson 1986). Purpose Statement The purpose of this cross-sectional survey study is to determine the impact of Packaging Elements on Consumer Buying Behavior in Pakistan. In this context Quantitative Method has been used, the purpose of this survey is to study the various packaging elements that influence the consumers buying behavior. The present study focuses on packaging elements including design, color, labeling, and innovations. Packaging is a wide term in which different elements describe and identify a product or service. It is considered a science, art and technology which not only protects, stores, and distributes a product but also helps the consumer in identifying a product (Wiki). Orth Malkewitz 2006; Underwood Klein 2002 argue that the importance of packaging is increasing due to the increased significance it is playing in buying decisions in store, the presence of it at the time of purchase decisions, and its ability to reach to a wider audience of product purchasers. Rundh 2005 further argues that packaging has the ability of differentiating products from each other. In todays global and competitive environment, packaging can also provide a source of competitive advantage. This study will identify the impacts of packaging elements on the consumer buying behavior in Pakistan using questionnaire survey method. Significance of Study The topic under research will study the impact of packaging elements on consumer buying behavior of Pakistan. For this purpose four packaging elements have been selected; packaging color, design, innovation and printed information. According to Cruden 1989, over the years the, introduction of new packaging concepts have accelerated. This study will be of value in a number of ways. The topic of research is highly under researched and least research has been done regarding the impact of packaging elements on consumer buying behavior of Pakistan. This study will not only help the marketers in bringing innovations and creativeness into the packaging of products but will also provide the policy makers in implementing effective decisions in bringing changes and creative strategies in packaging. This study will contribute immensely through Quantitative research. Research Objectives Main Objective The main objective of the study is to: To determine the impact of packaging elements on consumer buying behavior of Pakistan. Sub Objectives The sub objectives of the study are: To provide a basis for future research and to facilitate the administration in implementing and introducing effective and creative packaging elements in order to influence the consumers buying behavior in a positive way. Research Questions and Hypothesis Main Research Question Impact of Packaging Elements on Consumer Buying Behavior. Hypothesis H1 = Does package color influence the consumer buying behavior? H2 = Packaging design has an impact on consumer buying behavior? H3 = Does labeling influence the consumer buying behavior? H4 = Do innovations in packaging impact the buying behaviors? Literature Review Introduction Nowadays consumers have become more and more conscious about the packaging available to them from products. The role of packaging has changed over the years since primarily due to the changing lifestyles and needs of the consumers. Companies have started bring innovations in packaging since their beliefs over the years have changed that good and unique packaging can stimulate consumer buying behaviors. It has become the source of customers attraction towards products or services, increases the image of the brand and increases the perceptions of the consumer for the product (Rundh 2005), further argued by Rita Kuvykaite (2009) that a package attracts the attention of the consumers for a particular brand. In marketing context packaging plays a very vital role in communicating the product to the consumers and ultimately increases consumers purchase decisions. According to Underwood, Klein Burke, 2001; Silayoi Speece, 2004 a good package communicates unique values about products, and a lso helps in differentiating the products from other products, hence helping the consumers in choosing the right product from a wide range of similar products, and as a result stimulates consumers buying behaviors. (Wells, Farley Armstrong, 2007). It has become a significant issue that the consumers buying behaviors are influenced by the packaging elements. According to Kotler 2003 six packaging elements are the important elements that should be evaluated while employing packaging decisions, these include; size of package, package form, package material, color, text and the brand using that package. According to a study conducted by Bed Nath Sharma in 2008, the respondents response was 84.37% in which they responded that product labels are a simple tag which is attached to any product or consider it as a graphical design which an essential part of a package. In another study in support of packaging belongs to Alice Louw (2006) in which he studied the responses of university students in which it was concluded that in the marketing arena packaging has played a very vital role and he concluded that the right packaging helps in creating unique place in the market as well as in the minds of the consumers. In another research conducted by Renaud Lunardo (2007) the impacts of label on particular brand consumption showed that many consumers buying behavior has been influenced by the labeling. In support of packaging influencing the buying behavior of consumers another study has been conducted by Bytyqi Hysen Vegara Mensur (2008) on how consumers purchase or buy diary products in Kosovo. The results that generated from the research show that majority of the respondents feel that packaging has much to do while purchasing diary products. Various studies have found that packaging is a mean of attracting customers attention towards a product (Underwood et al., 2001; Garber et al., 2000; Goldberg et al, 1999; Schoormans Robben, 1997). Goldberg et al. (1999) emphasized that if non-verbal communication like colors etc, if they are removed from packaging and the use of verbal communication is increased (like images) then it highly attracts the customers specially when the brand in unfamiliar with the consumers. (Underwood et al., 2001). Futher it is argued that package color (Gordon et al., 1994), name of brand (Rigaux-Bricmont, 1981), and package material (McDaniel Baker, 1977) all communicate the meaning of the brand to the consumer. Despite these finding researchers argue that physical appearance is not all that attract consumers towards a particular brand (Garber et al., 2000; Schoormans Robben 1997) while others argue that package colors and shapes are the main source of product attraction and attention (Garber et al., 2000; Schoormans Robben 1997). According to a research conducted by Pires Gon (2008) it is unable for the consumers to preceive what a product is all about, they heavily rely upon the packaging of any product. So the essential packaging elements are the color and shape of the package as well as labeling which communicate the product message to the consumers. Literature Flow Diagram Summary Chapter 3 Methodology This chapter deals with the methodology used in investigating the collected data. A systematic way has been provided which includes the procedures taken for the purposes of data collection and analysis. Introduction For the purpose of this research Quantitative Research Method has been used. Paradigm: Research Approach: The research approach used in this study is Quantitative Research. For this purpose a self administered questionnaire was designed. Research Design: Quantitative research approach is implied in this study in which questionnaires will be undertaken for the purpose of data collection. The questionnaire respondents were the employees of the Telecom sector. (Sampling, validity reliability, cross sectional survey) Research Site: Population/Sample: For the purpose of data collection the site selected for this study includes general consumers from which the data has been selected. Strategy of Inquiry: Method: Data collection method was questionnaire which was self administered. The method of sampling was random sampling. Survey method has been used Validity and Reliability: Reliability means that the result is applicable whereas validity means that the measurement are accurate and whether they are measuring what they intend to measure. In reliability checked the results through statistical procedure of internal consistency. To increase the reliability of questionnaire a pilot test was made from 5 respondents. Errors and ambiguities were removed during this process. Analysis Procedure: After setting the sample size, site, the tool for data collection, various analyses were done using SPSS.

Antiglycation Studies of Pd(II)-Hydrazide Complexes

Antiglycation Studies of Pd(II)-Hydrazide Complexes Introduction Glycation is a non-enzymatic spontaneous reaction between sugars and coexisting protein followed by a complex cascade of reactions including dehydration, redox reaction and other rearrangements [1, 2] forming advanced glycation end products (AGEs) [3]. Glycation reactions depend on the generation of reactive oxygen species by trace amounts of redox active metal ions [4] and on the degree and duration of hyperglycemia in vivo [5]. Glycation damages the collagen and elastin throughout the body. It is generally accepted that accumulation of tissue AGEs together with enhanced oxidative stress has an important role in the progression of aging and diabetic complications including retinopathy, neuropathy, embryopathy, delayed healing of wounds and others [6-10]. The increase in diabetic complications is the major cause of increased morbidity and mortality rate that has enhanced considerably in the two decades [11]. It has been estimated that the number of cases of DM will reach to 366 milli on by 2030 [12, 13] showing in fact a great challenge to healthcare systems [14]. The failure of existing antidiabetic drugs are forcing researchers to find out new inhibitors of proteins responsible for glycation in order to have a long term and sustainable solution for management of diabetes and age-related diseases. Protein Glycation The protein glycation, also called Millard reaction, involves non-enzymatic coupling of proteins with reducing sugars eventually producing advanced end products. The glycation is a spontaneous reaction, which stimulates the degradation of proteins with modification of their structures and biological activity [1-3]. Various reducing sugars including glucose, lactose, fructose, xylose, deoxyribose and galactose may take part in protein glycation [15]. Chemistry and Mechanism of Protein Glycation The protein glycation process initiates with the reaction of carbonyl (keto or aldehydic) group of reducing sugar with free amino group of protein forming a labile Schiff base 16. This is called early stage of glycation. The Schiff bases are then transformed through Amadori rearrangement into comparatively stable compounds known as Amadori products. At acidic pH or under oxidative conditions, the Amadori products or Schiff bases undergo degradation generating extremely reactive 1, 2-dicarbonyl compounds, such as methylglyoxal (Figure 94) 17-21. The formation of protein dicarbonyls through a protein enediol may generate superoxide radicals in the presence of transition metal ions and molecular oxygen 22. The superoxide radicals can be converted into most reactive hydroxyl radical via Fenton reaction 7. The reactive carbonyl compounds subsequently react with amino groups of neighboring proteins producing protein dicarbonyl compounds, which further contribute in the formation of various types of protein crosslinks and adducts called ‘Advanced Glycation End Products’ (AGEs). The autoxidation of Amadori products to AGEs is described as glycoxidation process. Figure 94. Structures of some reactive dicarbonyl glycation intermediates Advanced Glycation End Products The advanced glycation end products (AGEs) comprise a complex heterogeneous group of compounds produced primarily through the reaction of reactive carbonyls and proteins. AGEs demonstrate to have diverse molecular biological functions and structures 18, 23]. The amino, sulphydryl and guanidinum functional groups occurring in the intracellular and extracellular proteins are the main targets of reactive carbonyl compounds. Various AGEs have been recognized in different tissues that can be categorized into three major groups: fluorescent cross-linked AGEs (e.g. pentosidine and crossline), non-fluorescent cross-linked AGEs (e.g. alkyl formyl glycosyl pyrrole and arginine-lysine imidazole cross-links) and non-cross linked AGEs (e.g. pyrraline and N-(carboxylmethyl) lysine) 18. The structures of some AGEs are presented in Figure 95. Figure 95. Structures of selected advanced glycation end products Factors Affecting the Formation of AGEs In physiological environment, the generation of AGEs is a relatively slow process. Accordingly, the AGEs accumulation is dominant in long-lived structural proteins, for instance, tissue collagens and lens crystallins. The oxidative conditions are known to accelerate the formation of AGEs, which slows down under anaerobic environment [24]. The transition metal ions may induce the auto-oxidation of sugars to produce keto aldehydes and hydrogen peroxide that speed up the formation of AGEs [25]. The amount of AGEs formed is increased as a function of time and concentration of glucose and hence the AGEs formation is enhanced with aging and under diabetic conditions [26]. Site Specificity of Glycation of Proteins Glycation of protein is considered as a specific reaction; however, it is less specific compared to enzymatic glycosylation. Glycation often takes place at specialized site in the protein, such as the substrate binding site (e.g. Arg-39) of RNase, the allosteric site (e.g. ÃŽ ²V1) of hemoglobin, and the drug binding sites (e.g. Arg-410) on albumin [27]. The specificity of glycation may be determined by endogenous ligands and the structure of protein especially an amino acid sequence within the protein. The specificity of protein glycation is usually affected by both basic and acidic neighboring groups [28], either via catalysis of Amadori rearrangement (the rate-limiting step of protein glycation), or via effecting pKa of amino group that contributes in enhancing its nucleophilicity and formation kinetics of Schiff bases. This shows that there is a variation in the respective rate and extent of glycation shown by amino groups in the protein. The anionic ligands also catalyze the pote ntial glycation of proteins at specific sites [27]. Exogenous Sources of AGEs The formation of AGEs via Maillard reaction was originally described for physical and chemical changes occurring during heating of food [29]. Beside the natural formation of AGEs inside the body, there are some exogenous sources of increased AGEs including diet enriched with AGEs and smoking. The extent of absorption of AGEs ingested with food is very small [30]. However, there is a strong relationship of AGEs circulating in the human body with the AGEs ingested [31]. It has been investigated that tobacco smoke increases the formation of AGEs on plasma proteins due to containing some products, which produce protein crosslinks and AGE-like fluorescence and mutagenicity [32]. For example, the diarbonyl compounds, glyoxal and metbylglyoxal, are most likely to be present in cigarette smoke that act as mediators of AGE formation and formed by thermal decomposition of existing saccharides. Accordingly, the serum of diabetic smokers reveals enhanced levels of AGEs relative to diabetic non-smokers [33]. Similarly, the smokers are more susceptible to incidence of cataract, cardiovascular and lungs diseases as compared to non-smokers due to smoke-mediated AGEs formation [34]. Toxicity or Pathological Conditions Associated to Glycation and AGEs Formation The AGEs are more prone to proteolysis and degradation as compared to the original proteins. The accumulation of AGEs has toxic biological effects, causing disruption of many cellular processes leading to various pathologies. The AGEs as well as intermediate glycation products such as reactive carbonyls induce the production of free radicals in vitro and in vivo [35, 36] and hence increased oxidative stress [37]. The glycation-mediated free radicals are the major cause of protein fragmentation as well as oxidation of lipids (lipid peroxidation) and nucleic acids [7]. The reactive dicarbonyls have ability to bind with naturally active proteins of diverse physiology via intra- and inter-molecular cross linking resulting in deactivation of enzymes, transcription factors, membrane transporters and signaling components with eventual protein degradation and cytotoxicity [38-40]. The AGEs also bind to cell membrane receptors inducing signal cascades leading to inappropriate gene expressions and cellular activities [18]. The elevated level of AGEs in tissues has a strong correlation with severity of diabetic complications [41, 42]. This is because of modification of enzymatic activity in multiple ways including binding of ligand, change in protein half life, increased membrane permeability, decreased binding ability of insulin to its receptors, increased atherogenicity of LPL and variation in the immunogenicity [43-45]. The main diabetic complications include impaired wound healing and the serious damage and failure of various vital organs such as kidneys (nephropathy), nerves (neuropathy), eyes (cataract, retinopathy), blood vessels (atherosclerosis) and heart (cardiomyopathy) [11, 34, 46, 47]. The AGEs formation is also associated to aging, Alzheimer’s disease and other chronic disorders [17, 10, 48-50]. Natural Biological Defense Mechanism against Glycation and AGEs The human body presents a certain mechanism to inhibit the glycation of protein and resulting AGEs formation. For example, ÃŽ ±-keto-glutaraldehyde dehydrogenase, a liver enzyme, has a capability to inactive 3-deoxyglucosone (3-DG), Arnadori-derived reactive intermediate and hence prevents the generation of AGEs [41]. The other enzymes such as aldose reductase and glyoxylase system (I and II) can catalyze the deglycation of reactive intermediate methylglyoxal into D-lactase [51]. Amadoriases are the group of enzymes found in Aspergillus, which catalyze the deglycation of Amadori products [52]. Some NADPH-dependant exogenous enzymes such as aldose reductase and oxoaldehyde reductase that metabolize ÃŽ ±-dicarbonyls, have the ability to reduce 3-DG and thus regulate the formation of AGEs [53]. Similarly, different plasma amines may reduce AGEs formation through reaction with carbonyl groups of sugar and Amadori compounds [54]. Antioxidants such as vitamin E and vitamin C, provide prote ction against glycation-mediated free radicals, whereas, ceruloplasmin and other transport proteins bind with transition metal ions such as Cu2+, preventing them to take part in glycoxidation reactions or autoxidative glycation [55]. Inhibition of Protein Glycation and AGEs Several attempts have been made earlier to explore pharmacologically active antiglycating agents to prevent or slow down the production of AGEs [56]. The major side effects associated with antiglycation therapy limit the use and necessitate the discovery of new inhibitors of glycation with reduced toxicity and long half life to be implicated for large time span. Currently, two therapeutic strategies are highly successful having great effectiveness against diabetic complications and normal aging; one is the inhibition of formation of AGEs and other is the breaking of already established AGEs cross-linkages [57]. Promising Inhibitors of Glycation with Their Mechanism of Inhibition The antiglycating agents such as aminoguanidine, rutin, antioxidants, aspirin and other AGEs breakers have been examined extensively and received great interest. The structures of some potential antiglycating agents are depicted in Figure 96. Aminoguanidine Aminoguanidine is a derivative of hydrazine that inhibits the generation of AGEs and glucose-derived collagen cross-links during in vitro studies [58]. Aminoguanidine does not act on already formed AGEs but it reacts with reactive Amadori products such as 3-deoxyglucosone preventing additional rearrangements and intermediates crosslinking [59]. In addition, aminoguanidine is a free radical scavenger that contributes in reducing oxidative stress [60]. The treatment of diabetic animal models with aminoguanidine reduces AGEs accumulation, kidney lesions, albuminuria and long-term diabetic complications including retinopathy, nephropathy and neuropathy [61]. Aminoguanidine also exerts positive effect on the speed of nerve conduction [22]. Aminoguanidine therapy is limited by serious toxic effects attributable to high reactivity, subliminal concentrations and rapid renal clearance. The human trials with aminoguanidine experience vasculitis (inflammation of lymph or blood vessel), liver fu nction abnormalities [62] and less frequent flu-like symptoms, nausea and headache [63]. Figure 96. Structures of some potential antiglycating agents Aspirin Acetylsalicylic acid commonly known as aspirin is an analgesic has well known analgesic drug that also shows the preventive action against formation of cataract under diabetic conditions. Aspirin may limit the sugar-mediated formation of Amadori products by acetylation of free amino residues of proteins. Aspirin also stops the crosslinking of tendon in rat tail in vitro through inhibition of glycoxidation. Furthermore, aspirin is a free radical scavenger [64]. However, the use of aspirin is unlikely in controlling late diabetic complications because of some serious gastrointestinal side effects [41]. Rutin Rutin is a common flavonoid of vegetables and fruits that modulates the AGEs generation in vitro. The flavonoids including rutin that contain vicinal dihydroxyl groups have established their significant role as antiglycating agents. The mechanism of inhibition by rutin is suggested to involve the trapping of amino groups in proteins at early stage of glycation, especially in ketoamine formation, by rutin metabolites like keto-quinone intermediates. Rutin has shown significant inhibitory effect against hemoglobin glycation and it is more efficient compared to aminoguanidine [65]. Antioxidnats Since non-enzymatic glycation of protein is significantly accelerated by excessive generation of free radicals, the antioxidants and other free radical scavengers are expected to inhibit the process of glycation [24]. For example, vitamin E has been reported to appreciably reduce the glycation of hemoglobin [66]. The compounds that exhibit both antioxidant and antiglycation properties e.g. aminosalicylic acid, can protect endothelial cells with better efficacy than aminoguanidine against adverse effects of glycation and high glucose levels in vitro [46]. Similarly, carnosine that is a naural antioxidant and antiglycating agent, inhibits sugar-induced cross-linking of proteins by reaction with methylglyoxal and also sequesters metal ions (e.g. copper and zinc). Carnosine has shown its role in the treatment of cataracts and other diseases [67]. The glycation-derived free radicals generation may be reduced by chelation of transition metal ions, which are responsible for monosaccharide a utoxidation. For instance, the metal chelator, diethylenetriamine penta acetic acid has shown the inhibition of glucose autoxidation [68, 69]. AGE-Breakers AGE-breakers are the compounds, which remove AGEs cross-links through breakdown of ÃŽ ±-dicarbonyl bonds in glucose-derived cross-links of proteins [70]. However, the exact mechanism of inhibition for cross-link breaking is unclear so far. N-phenacylthiazolium bromide (PTB) and its chloride form, alagebrium chloride (ALT-711) are the examples of AGE-breakers. It has been demonstrated that the increased arterial stiffness related to diabetes is successfully reversed through a short treatment with AGE-breaker, ALT-711. The cardiovascular stiffness related to normal aging process can also be reduced by ALT-711. For example, the treatment of normal aged dogs with AGE cross-link breaker has shown noticeable decrease in stiffness of left ventricle chamber [71]. The clinical trial studies on diabetic humans, dogs and other animals indicate the potentially promising use of antiglycation therapy in near future to prevent diabetic complications and other diseases related to protein glycation [56].

The Life of Kate Chopin Essay -- Biography Biographies Essays

The life of Kate Chopin      Ã‚  Ã‚   Kate Chopin led a fascinating life filled with times of triumph but also times of great loss. Living in the South during the post-Civil War era, the setting and experiences of her life would have a great impact on the subjects of her writing. Chopin began writing as a way to express her frustration with life. This is why her emotions about life are conveyed so strongly in her writing. One of her short stories, "Juanita," is an excellent example of how Chopin's life affected her writing.   Ã‚  Ã‚  Ã‚   The story of "Juanita" is that of a young woman who, though not incredibly beautiful, had many admirers. The people of her small town gossiped continually about which man she would marry. Would it be the man who had traveled all the way from the city for the sole purpose of seeing her? Or would it be the rich millionaire from Texas who owned a hundred horses? The townspeople all assumed she would choose the richest of her suitors, until one day Juanita announced that she had secretly married a poor one-legged man whom she loved very much.   Ã‚  Ã‚  Ã‚   To truly understand the characters of Chopin's stories, one must examine the history of her life. Kate Chopin was born as Katherine O'Flaherty to a wealthy Irish St. Louis family on February 8, 1851. While she was still a young child, her father died in a train accident. Only a few years later her brother died after being captured by Union forces during the Civil War. The loss of all the males in her life, according to Hoffman, led to the intense female relationships she shared with her mother, grandmother, and great-grandmother. As a young woman, Kate treasured her independence. Late 1860's society was highly critical of her because she walked, unac... ... about the world as she actually saw it. For a woman to do this in the late nineteenth century was unheard of, and Chopin was highly criticized for it at the time. But after going through as much as she did in her life, she could not stay silent. Ker suggests that "after 39 years of trials and tribulations and just plain living, she finally had something to say!"    Works Cited Chopin, Kate. "Juanita." A Vocation and a Voice Stories. Ed. Emily Toth. New York: Penguin Books. 1991. 86-88 Chopin, Kate. The Awakening. New York: Bantam Books. 1988 Fox-Genovese, Elizabeth. "Kate Chopin: A re-awakening." http://www.pbs.org/katechopin/interviews.html Hoffman, Audrey. "Kate Chopin." http://www.kutstown.edu/faculty/reagan/chopin.html Ker, Christina. "Kate Chopin- Ahead of her Time." http://empirezine.com/spotlight/chopin/chopin1.htm         

Analyse the case study with reference to Michael Porter’s Theory :: Business and Management Studies

Analyse the case study with reference to Michael Porter’s Theory of Competitive Advantage and answer the following question: Does America have competitive advantage in the textile and garment industry? Analyse the case study with reference to Michael Porter’s Theory of Competitive Advantage and answer the following question: Does America have competitive advantage in the textile and garment industry? You answer must include the following elements: 1. A clear outline of Porter’s theory with supporting references. 20% 2. An analysis of the case study with reference to the 4 main elements of Porter’s Diamond. (N.B. You will not be able to comment on company structure, as the case study does not include information on this. You should, however, refer to factor conditions, demand conditions, firm rivalry and related and supporting industries.) 40% 3. An analysis of the case study with reference to Porter’s secondary points of chance and government actions. 20% 4. Your conclusion. 10 % The remaining 10 % will be for grammar, style, clarity, using the correct system of referencing (the Harvard System) etc. Literature: Michael E. Porter. The Competitive Advantage of Nations. Does America have competitive advantage in the textile and garment industry? For a country to have a competitive advantage, it is necessary to understand Michael Porter’s Theory of National Competitive Advantage. Michael Porter introduced a model that allows analysing why some nations are more competitive than others are, and why some industries within nations are more competitive than others are, in his book The Competitive Advantage of Nations. This model of determining factors of national advantage has become known as Porters Diamond. It suggests that the national home base of an organization plays an important role in shaping the extent to which it is likely to achieve advantage on a global scale. This home base provides basic factors, which support or hinder organizations from building advantages in global competition. Porter distinguishes four determinants: Factor Conditions The situation in a country regarding production factors, like skilled labour, infrastructure, etc., which are relevant for competition in particular industries. These factors can be grouped into human resources (qualification level, cost of labour, commitment etc.), material resources (natural resources, vegetation, space etc.), knowledge resources, capital resources, and infrastructure. They also include factors like quality of research on universities, deregulation of labor markets, or liquidity of national stock markets. These national factors often provide initial advantages, which are subsequently built upon. Each country has its own particular set of factor conditions; hence, in each country will develop those industries for which the particular set of factor conditions is

Advantages of a Web-Based System

Efficiency is Everything One of the essential characteristics of the Internet Age is speed.   As a matter of fact, companies – whether large or small – cannot gain a competitive edge in our times without the use of the World Wide Web in their day to day activities.   The Internet speeds up communication, thereby allowing collection agencies to pursue debt payments faster than before.   Moreover, the collection of debts can be speeded up by the employment of a web-based system at Cougar Collection Agency. Another important advantage of a web-based system is that it would allow you to view the accounts even as you travel.   Clients would be given real time access to information through their own web browsers.   Furthermore, Cougar Collection Agency may employ data entry clerks and collectors to work from their homes – thereby cutting costs (â€Å"Web Access,† 2007). State-of-the-art web-based systems are available at reasonable costs Collect!’s Web Host is only one of many companies willing to help Cougar Collection Agency in collecting payments more efficiently than before.   The company creates web-based systems for collection agencies at reasonable costs.   These systems are â€Å"fully integrated and easy to set up;† â€Å"highly customizable;† as well as secure (â€Å"Web Access†). Conclusion Indeed, Cougar Collection Agency would be able to reduce costs while increasing efficiency by the employment of a web-based system. References Web Access. (2007). Collect! Retrieved Nov 7, 2007, from http://www.collect.org/webaccess.html.   

Remote Desktop

Ever wished you could access your PC from the road? With Remote Desktop inWindows 7, you can. Remote Desktop connects two computers over a network or the Internet. Once connected, you'll see the remote computer's desktop as if you were sitting right in front of it, and have access to all its programs and files. This feature is included with all editions of Windows 7, but you can only connect to computers running the Professional, Ultimate, or Enterprise editions. Use Remote Desktop to access one computer from another remotely. For example, you can use Remote Desktop to connect to your work computer from home. You will have access to all of your programs, files, and network resources, as if you were sitting in front of your computer at work. While you are connected, the remote computer screen will appear blank to anyone at the remote location who sees it. Server and Client Requirements The computing model for thin-client networking means that the horsepower is concentrated on the server end, not the client end. Because the server will be supporting dozens of people — maybe hundreds — this is not the time to skimp on power. Server Hardware The notion of using a bigger server so that you can skimp on client-side hardware isn't new. That's all a file server is: a computer running a big, fast hard disk so that you don't have to buy big, fast hard disks for everyone in the office. RDS servers are designed on a similar principle — if most of the processing takes place in a single location, you can concentrate the hardware resources needed to support that processing in a single location and worry less about power on the client end. Use a Powerful RD Session Host Server Since an RD Session Host server will be serving applications or full desktops to clients, you'll need to purchase or build a powerful server. Processing power and RAM are the most important resources. Depending on the types and number sessions you're supporting, you may also want to consider boosting disk access and network bandwidth. On the surface, calculating the needs seems straightforward. Just follow these steps: 1. 2. Calculate the resources needed for the operating system. 3. . Calculate the resources needed for a small number of sessions (such as five). 5. 6. Multiply the resources needed for your sessions based on the total number of sessions you plan to support. If you planned to support 100 sessions and you measured five sessions, you'd multiply by 20 (20 * 5 = 100 sessions). 7. 8. Add the total session resources needed for sessions to the resources needed for the operating system. Although this seems like simple math, it never seems to work out that way. Synergy is often hard to predict. Synergy (where the whole is greater than the sum of its parts) often results in something unexpected. Additionally, if the deployment is successful and users are happy with what they can do, they may end up using it much more than you anticipated. You don't need to tell this to the budget people, but it's best to add a buffer for the unknowns and to plan for expansion. Additionally, you should do some independent research starting with Microsoft's Remote Desktop Services home: www. microsoft. com/windowsserver2008/en/us/rds-product home. aspx. Core Hardware Resources For the purposes of running an efficient RD Session Host server, the bare minimum required to run Server 2008 R2 won't cut it. Although there are no hard-and-fast specifications for an RDS server, some general guidelines for server sizing follow: Processor Faster is better to a point. More important than a fast processor is one with enough cache so that it doesn't have to reach out to the (slower) system memory for code and data. Faced with a choice between more cache and more speed, go with more cache. Most RDS servers these days have multiple processors, and these processors have multiple cores. Although only multithreaded applications will actually use more than one processor at a time, if there are multiple processors, then threads needing execution can line up at both. Memory RDS servers tend to be memory bound, not processor bound. Get high-speed, error-correcting memory; get plenty of it; and be prepared to add more as you add more users or applications to the RDS server. The amount of memory you'll need depends on the applications that people use, the number of concurrent sessions, and the memory demands of the files opened in those sessions — computer-aided design (CAD) programs will stress the system more than, say, Notepad. Thankfully, the 64-bit operating system goes well beyond the 4GB limit. Start your calculations with at least 8GB of RAM for the server, and start adding based on the of number of users and memory required by the applications they'll run on the server. Windows Server 2008 R2 will support up to 2TB of RAM. Disk Consider Serial Computer System Interface (SCSI) disks on an RDS server if at all possible. A SCSI disk controller can multitask among all the devices in the SCSI chain. Most people believe that SCSI performs much better both Serial Advanced Technology Attachment(SATA) and Enhanced Integrated Drive Electronics (EIDE) disks, though some people are starting to find that high-end SATA solutions perform better than low-end SCSI solutions. Disk performance is an important capability in any server, especially so in an RDS server. Additionally, consider a Redundant Array of Inexpensive Disks (RAID) solution to increase the performance and/or fault tolerance of the drives. For a high-end RDS server, a RAID 1+0 solution provides both performance gains and redundancy. Network On a busy RDS server, consider load-balancing high-speed network cards, which can assign multiple NICs to the same IP address and thus split the load of network traffic. Another alternative is a multihomed server with one NIC dedicated to RDS session traffic. As far as network speed goes, sending application output and client-side input back and forth requires little bandwidth, but client-print jobs sent to mapped printers can take quite a bit of bandwidth. Mapped drives may also increase the load by making it possible to copy files back and forth across the RDP connection. Using the Performance Monitor The Performance Monitor (discussed in Chapter 17) can help you get an idea of how RDS sessions are stressing the server. Server load should scale closely with the number of people using the server; therefore, as long as you pick a representative group of about five people, you should be able to extrapolate your needs for larger groups. The key objects and counters for measuring eneral server stress introduced in that chapter will help you size your RDS servers. But a couple of Performance Monitor objects are worth examining to give you detailed information for your RDS server. Performance Monitor Objects Still Called Terminal Services Although the name of Terminal Services has changed to Remote Desktop Services in Windows Server 2008 R2, it's still called Terminal Services in Performance Monitor. It might look like a typo, but the two ob jects are called Terminal Services and Terminal Services Session. First, the Terminal Services object has counters representing the number of active sessions (sessions where the user has connected to the RD Session Host server and successfully logged on), inactive sessions (where the user is still logged onto the RDS server but has stopped using the session), and the total combined. Besides simply monitoring activity, you could use this to alert you when the number of active session reaches a certain threshold. Say you wanted to know when a server hosts more than 100 sessions. You could do this with a data collector set. Chapter 17 discussed data collector sets in more depth, but it's possible to set up a simple user-defined data collector set with an alert. This is done by creating the user-defined data collector set manually (not with a template), selecting Performance Counter Alert, and then setting the threshold for the active sessions. You can then set a task for the alert to notify you with a basic script or log the event to a file. Although you can get some session-level information from the Remote Desktop Services Manager, a performance object called Terminal Services Session provides quite a bit more data. Use the Remote Desktop Services Manager to find the session you want to monitor — sessions are identified in Performance Monitor by their session numbers, not user login name — and then add counters to monitor that session. Each session object has processor and memory counters that should look familiar to anyone who's used Performance Monitor, but it also has session-specific counters such as the ones in Table 25. 1. We haven't included all the counters here, just the ones to show you the kind of information that will be useful when you're calculating the load on the server and looking at the kind of performance the sessions are getting. Table 25. 1: Key Terminal Services Session Performance Monitor Counters Counter| Description| See Also| % Processor Time| Percentage of time that all of the threads in the session used the processor to execute instructions. On multiprocessor machines the maximum value of the counter is 100 percent times the number of processors. | | Total Bytes| Total number of bytes sent to and from this session, including all protocol overhead. | Input Bytes, Output Bytes. | Total Compressed Bytes| Total number of bytes after compression. Total Compressed Bytes compared with Total Bytes is the compression ratio. | Total Compression Ratio| Total Protocol Cache Hit Ratio| Total hits in all protocol caches holding Windows objects likely to be reused. Hits in the cache represent objects that did not need to be re-sent, so a higher hit ratio implies more cache reuse and possibly a more responsive session. | Protocol Save Screen Bitmap Cache Hit Ratio, Protocol Glyph Cache Hit Ratio, Protocol Brush Cache Hit Ratio| Working Set| Current number of bytes in the Working Set of this session. Virtual Bytes, Page Faults/Sec| Wait on the License Server When experimenting with Remote Desktop sessions to find out how many users you'll be able to support for each session, do not set up a license server; let the RDS server issue its temporary 120-day licenses for this purpose. Although this sounds counterintuitive, using the temporary licenses prevents you from unwittingly assigning per-device licenses to test equipment. See the  "Licensing Mode† section for an explanation of how licensing and license allocation works. Client Hardware. When connecting to an RD Session Host server via a native RDP client, you'll most often use a PC with a Windows operating system loaded, a Windows terminal, or a handheld PC using Windows CE. Native RDP Client In this context, a native RDP client means one available from Microsoft and thus implies Windows. Although Microsoft does not support other platforms (except for its OS X Macintosh client, available for download at www. microsoft. com/mac/products/remote-desktop/default. mspx), Hobsoft link sells a cross-platform (Windows, Mac, Linux, DOS) Java client at www. hobsoft. com/products/connect/jwt. sp, and there is a free Linux RDP client available at www. rdesktop. org. Windows Terminals In its narrowest definition, a Windows terminal is a network-dependent device runningWindows CE that supports one or more display protocols such as RDP or Independent Computing Architecture (ICA), the display protocol used to connect to Presentation Server servers. Many Windows ter minals also support some form of terminal emulation. For this section, think of a Windows terminal as any terminal device designed to connect to a Windows RD Session Host server; it can run any operating system that has an RDP client. A Windows-based terminal (WBT) is such a device that's running a Windows operating system locally — CE or (more rarely) Windows XP/Vista for Embedded Systems — and follows the Microsoft system design requirements for WBTs. The main thing defining a Windows terminal is its thin hardware profile: because the main job of most Windows terminals is to run a display protocol, they don't need much memory or processing power, and they don't use any storage. A Windows terminal includes a processor; some amount of memory, network, and video support; and input devices such as a keyboard (or equivalent) and mouse (or equivalent). The terminals don't generally have hard disks, CD-ROMs, or DVD players. The operating system is stored in local memory. Beyond those similarities, Windows terminals range physically from a â€Å"toaster† form factor to a pad to a small box that can attach to the back of a monitor — or even be part of the monitor itself. Some models of Windows terminals are wireless tablets, intended for people (such as doctors and nurses) who would ordinarily use clipboards and folders to store information. Although most Windows terminals are entirely dependent on their RDS server, a small set of them can run applications locally. The devices still don't have hard disks; the applications are stored in ROM like the operating system. The types of applications available depend on the terminal's operating system, since locally stored applications must run locally instead of just being displayed. Generally speaking, however, it's more common for Windows terminals to depend on an RDS server for applications. Windows terminals are most popular in environments where people are using a single application, where supporting PCs would be logistically difficult, or anywhere else that PCs aren't a good fit. However, PCs still outnumber Windows terminals as thin clients. Part of this is because many environments can't depend totally on server-based computing. Companies already have PCs, and unless they're refreshing the desktop entirely, taking away a powerful PC to replace it with a less-powerful terminal doesn't really make sense. PC Clients At this point, people are using more than twice as many PCs as Windows terminals for RDS server client machines. This isn't surprising. First, unless they're starting fresh, people already have the PCs. Even though WBTs are a little less expensive than low-end PCs (not much, though), they're still an added cost. Second, not all applications work well in an RDS server environment. It's often best to run some applications from the RDS server and some locally. Unless you're buying new hardware and don't anticipate any need to run applications locally, you're likely to have to work with PCs for at least some of your terminal clients. To work with Remote Desktop Services, the PCs must be running a Windows operating system, have the RDP display protocol installed, and have a live network connection usingTCP/IP and a valid IP address. Handheld PCs We're surprised that handheld PCs (H/PCs) aren't more popular than they are, given how handy they are. They're a terrific substitute for a laptop — inexpensive, lightweight, and thrifty with their power so that you can actually use them during the entire flight instead of having to give up two hours after takeoff. (You can also use one on a plane without worrying that the person in front of you will suddenly recline their seat and crack your laptop's display. ) Usually, they run Windows Mobile (previously known as Pocket PC). You can use wired, wireless LAN, or dial-up connections to connect to an RDS server. What an H/PC looks like depends on who makes it. Some (mine among them) look like a laptop's baby brother. Others fold into a little portfolio shape or are a flat tablet. Some are small pocket-sized deals that are too small to really work on. Some — the ones we prefer — have keyboards; others have only pointers. What all this comes down to is that an H/PC isn't really in a position to replace a desktop PC. Instead, it's usually used in cooperation with a desktop machine with which it's partnered